To best navigate ad blockers, I suggest concentrating ad dollars on the social media platforms themselves, and not ad networks. This means shifting from programmatic buying to directly buys. Whether on Facebook, LinkedIn, Instagram, Twitter, etc., visitors typically access these sites via an app (as opposed to a browser), and the social network controls the experience.
Most ad blockers use domain-level technology to block ads, and by going directly to the platform, you can avoid being stifled by blockers.
Have you tried programmatic ads? What’s been your experience vs the “native” ads on social media platforms?